Experimental permutations in science are straightforward. It is easy to run another set of experiments, just add another level to an establishing variable or cross two establishing variables. Experimental permutations guarantee small, limited returns by exploring the known space. It solves the interpolation problem by filling in current knowledge gaps.
The hard work of science is experimental extrapolation. Creating a new variable. Going into unknown space. Most results will be zero. However, the great work of science is there.
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